Changes in already excisted excel file

[C# Programming]

Hi i have a Already existed excel file in my root path of the application,

In tht i have to clear particular cells range like A2 to F75.

And i have insert my new datas into those cells,after tht its has to getting save on enduser side,
Please guide me,any one having idea baout this

Thanks & Regards,
Member 3879881,
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