C, VB.net, MySql

I have developed one GUI in vb.net but now I want to use C as backend code along with MySql as database.
Is it possible to create such a application.

I have been using C and MySql under Fedora and I have my GUI ready in vb.net. Can you tell me how can I communicate these thing together?

For ex. I have add button on front end, when I click add button, and instead of defining functionality in vb.net I want to send input to C function and then C function will execute and return output.